48 Hours in Rome: Simple Itinerary

Rome is busy, walkable, and packed with sights close together. In 48 hours, the goal isn’t to see everything—it’s to cover the main highlights.

Day 1: Ancient Rome + City Centre

Day 1: Ancient Rome + City Centre

Start early at the Colosseum. Book a timed ticket in advance or you’ll probably queue for a long time for the ticket. Spend about 1–2 hours inside. Walk straight next to the Roman Forum and Palatine Hill. It’s all one area, so don’t overthink the route—just follow the signs and explore for another 1–2 hours. Grab lunch nearby (there are plenty of basic tourist-friendly spots around Via dei Fori Imperiali).After lunch, walk toward the city centre:

  • Trevi Fountain (usually crowded but quick stop)
  • Spanish Steps (close by)
  • Pantheon (worth going inside if time allows)

Late afternoon: wander, sit in a café, or shop around the centre. Don’t over-plan this part. Dinner: pick a simple trattoria in the Centro Storico area. Book ahead if possible.

A trattoria is a small, casual Italian restaurant. Simple food, local dishes, usually family-run, cheaper than formal restaurants.

Day 2: Vatican City + Trastevere

Start early at the Vatican Museums. This takes 2–3 hours minimum. If you want to see the Sistine Chapel, you’ll go through the museums route.

  • Enter Vatican Museums
  • Walk through galleries
  • End at Sistine Chapel
  • Exit near St. Peter’s Bassilica area

Then visit St. Peter’s Basilica (entry is free, but airport style security lines can be long).

St Peter’s Basilica

Lunch near Prati or cross the river.

Afternoon: head to Trastevere. Walk around, explore streets, and relax. No strict itinerary here—just see the neighbourhood.

Trastevere is a historic Rome neighbourhood known for its narrow cobbled streets, lively atmosphere, and traditional restaurants. It is on the west bank of the Tiber River.

If you still have energy, climb up to Gianicolo Hill for a good view of the city. Dinner in Trastevere is a solid final meal—more local feel, good atmosphere, less chaotic than the centre.

That simple 48-hour Rome itinerary helps you see the main highlights without rushing, but it’s always flexible—you can skip or swap places depending on your pace and interests.